|
WEKSLER,
MARC E.
WRIGHT
PROFESSOR OF MEDICINE
EDUCATION/TRAINING
Swarthmore
College Swarthmore, PA, BA 1958 Zoology
College
of Physicians and Surgeons, Columbia Univ. MD, 1962 Medicine
RESEARCH AND PROFESSIONAL
EXPERIENCE
1964-66 Research Associate, National Cancer
Institute, NIH, Bethesda, MD (Drs.
Schimke, Gelboin)
1966-67 Fellow in Nephrology, Georgetown
Univ. Hospital, Washington, DC (Dr. Schreiner)
1967-68 USPHS Fellow in Transplantation
Immunology, St. Mary’s Hospital, London, (Pr. W. S. Peart)
1968-70 USPHS Special Fellow, Transplantation, Cornell
Univ. Med. College NY, NY (Dr.
A. L Rubin)
1970-75 Assistant
Professor of Medicine, Cornell
Univ. Med. College, NY, NY
1775-78 Associate
Professor of Medicine, Cornell
Univ. Med. College NY, NY
1978-1998 Chairman
of Geriatrics Cornell
Univ. Med. College, NY, NY
1978-Present Wright
Professor of Medicine, Cornell
Univ. Med. College, NY, NY
Honors
Alpha Omega Alpha, Clinical Scholar, American
Cancer Society; NIH Research Career Development Award, 1974-79; Elected
American Society for Clinical Investigation, 1977; Elected Fellow Gerontology Society of America,
1978; Elected Association of American Physicians, 1985; NIH MERIT Award, 1989; Elected, Interurban Clinical
Club, 1992; Elected Fellow Royal Society of Medicine, 1993,Visiting professor: Amer. Ass. Med. Coll. PR China 1983; Univ. Mich. 1985;
Pasteur Institute 1987-2002; University of Nagoya, Japan, 1995; Tokyo
Metropolitan Geriatric Center, 2000, University Monastir, Tunisia, 2005
Named
Lectureships
Law Lecturer, Cornell University, 1981; University of Notre Dame Lecturer, 1984; Fisher Scientific Lecturer, 1987; Koch
Institute, Berlin, 1995; Aging, Institute Cochin, Paris, 2000
Plenary Speaker
First International Conference Immunology and Aging, 1996; 5th
Congress on the Molecular Biology of Aging, 1997; Institute Cochin, Paris, 1999;
Merieux Foundation, 1999; Danone Conference Successful Aging, 1999; OECD International
Meeting on GM Foods, 2000, European Aging Consortium, 2002
Public ServiceNIH, Aging Review Committee, 1975-79; Associate Editor:J.
Immunol. 1976-82; Chairman, FASEB Summer
Conference: Development and Senescence of the Immune Response, 1984; Chair. New
York Acad. Med. Geriatric Medicine, 1985-1986; Chair, Amer. Coll. Phys, Geriatrics Committee, Self-Assessment
Program, 1986-1989 Chair, Aging Immunology Program, WHO, 1988; Chair, FASEB,
Aging and the Immune Response, 1990; Chair,
Audit Committee, Dutch Inst. Exp. Geront.; 1991 President, American Federation
for Aging Rersearch, 1992-94; Chair, Pfizer/American Geriatric Society
Fellowships, 1993; NIA-NIAID Taskforce on Immunology and Aging; Consultant,
Biotech. Direct. OECD, Paris 1999; Geriatric and Gerontology Consultant, Fonds
National de la Recherche, Luxembourg, 2001 Associate Editor
J. Immunol.1976-82
Editorial BoardsJ. Immunol. 1974-80; J. Geront, 1979-1982; Ann. Intern. Med. 1980-1983; J.Geront. Med. Sci, 1987-1992; New Frontier Editor,
Geriatrics, 1994-2000; Drugs and Aging, 1990-Present; Clin. Diag. Lab. Immun.,
1994-Present; Exp. Geront., 2000-Present, J. Clin. Immunol. 1995-present,
Immunity-Aging, 2004-present
PUBLICATIONS (principal publications through 2006)
Russo, C. Cherniak,
E.P., Wali, A. and Weksler, M.E. Age-dependent appearance of non-MHC restricted helper T cells. Proc. Natl. Acad. Sci. USA 90: 11718-11722, 1993; Ben-Yehuda, A.,
Szabo, P., Dyall, R. and Weksler, M.E. Bone marrow declines as a site of B cell precursor
differentiation with age: Relationship to thymus involution. Proc. Natl.Acad. Sci. USA 91:11988-11992, 1994;Nobrega, A.,
Haury, M., Gueret, R., Coutinho, A., and Weksler, M.E. The Age-associated
Increase in Autoreactivity
Reflects a Global and Progressive Expansion of Autoreactivity Detectable in
Young Mice.Scand. J. Immunol. 44:437-443, 1996 Schwab, R., Szabo,
P., Manavalan, J.S.,Weksler, M.E., Posnett, D. N., Pannetier, C., Kourilsky, P., and Even, J Expanded CD4+ and CD8+ Clones in Elderly
Humans. J. Immunol. 158:4493-4499
(1997) LeMaoult, J., Delassus, S., Dyall, R., Nikolic-Zugic, J Kourilsky, P.
and Weksler, M.E. Clonal Expansions of B Lymphocytes in Old Mice, J. Immunol. 159:3866-3874, 1997; LeMaoult, J., Szabo,
P., and Weksler, M.E. Effect of Age on
Humoral Immunity, Selection of the B cell Repertoire and B cell Development. Immunological
Reviews 160:115 1997 Szabo, P., Zhao, K.,
Kirman, I., Dyall, R. Cruickshank, and Weksler, M.E.. Maturation of B
cell Precursors Impaired in Thymic-deprived Nude and Old Mice. J. Immunol.161:2248-53,
1998; Kirman, I., Zhao, K-S, Wang, Y-F, Szabo, P. and Weksler, M.E. Increased Apoptosis of Bone Marrow Pre-B Cells in
Old Mice Associated with Their Low Number Int.Immunol.10:1385,1998; Ben-Yehuda
A, Szabo P, LeMaoult J, Manavalan JS, Weksler ME. Increased VH11 and VHQ52 gene in splenic B cells in old mice with
oligoclonal expansions of CD5+ B cells Mech
Ageing Dev 103:111 1998; LeMaoult J, Manavalan
JS, Dyall R, Szabo P, Nikolic-Zugic J, Weksler ME Cellular basis of B cell clonal populations in old mice. J Immunol.
162:6384-91 1999; Lacorazza HD, Guevara
Patino JA, Weksler ME, Radu D, Nikolic-Zugic J. Failure of Rearranged TCR Transgenes to Prevent Age-Associated
Thymic Involution. J Immunol 163:4262-4268, 1999; Weksler ME. Changes
in the B-cell repertoire with age. Vaccine. 181624-1628, 2000; Radu, DL, Antohi,
S, Bot, A, Weksler, ME and Bona, C. Plasmid Expressing the Influenza HA Gene Protects Old Mice from Lethal Challenge
with Influenza Virus. Viral Immunol.
12:217-226 1999. Weksler ME. Changes
in the B-cell repertoire with age. Vaccine. 18: 1624-1628, 2000; Weksler
ME, Szabo P J., The effect of age on the B-cell repertoire, J. Clin Immunol
20:240-9 2000.; LeMaoult J, Messaoudi I, Manavalan JS, Potvin H, Nikolich-Zugich D, Dyall R, Szabo P, Weksler ME, Nikolic-Zugic J. Age-Related Dysregulation
in CD8 T Cell Homeostasis: Kinetics of a Diversity Loss. J Immunol. 165:2367-2373. 2000; Karadimitris A,
Manavalan JS, Thaler HT, Notaro R, Araten DJ, Nafa K, Roberts IA, Weksler ME, Luzzatto. Abnormal
T-cell repertoire is consistent with immune process underlying the pathogenesis
of paroxysmal nocturnal hemoglobinuria. Blood. 96:2613-20. 2000; Li, F.Jin, F,
Freitas, A., Szabo, P., Weksler, M.E. Impaired Regeneration of the Peripheral B Cell Repertoire from Bone Marrow Following Lymphopenia in
Old Mice. Europ. J. Immunol. 31:500-505,
2001; Radu DL, Weksler ME,
Bona CA. Maintenance of size and function of influenza virus hemagglutinin specific transgenic T-cell clone during
life. J Cell Mol Med. 5:388-96.2001; Weksler M, Goodhardt
M. Do age-associated changes in 'physiologic' autoantibodies contribute to infection, atherosclerosis, and Alzheimer's
disease? Exp Gerontol. 37:971 2002; Li F, Yarilin DA, Valiando J, Ronco A, Weksler ME, Szabo P, Posnett DN. Tumor antigen drives
a persistent oligoclonal expansion of CD8+ T cells in aged mice. Eur J Immunol. 32:1650-8 2002.; Weksler ME, Relkin N,
Turkenich R, LaRusse S, Zhou L, Szabo P. Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide
antibodies than healthy elderly individuals. Exp Gerontol. 37:943-8 2002; Weksler ME, Goodhardt
M, Szabo P. The effect of age on B cell development and humoral immunity. Springer Semin Immunopathol. 24:35-52. 2002; Posnett DN, Yarlin D,
Valiando JR, Li F, Liew FY, Weksler, ME, Szabo, P, Oligoclonal Expansions of Antigen-Specific CD8+ T cells in Aged
Mice. Ann. NY Acad. Sci.987:1-6, 2003; Szabo P, Shen, S., Telford, W., Weksler, ME Impaired
rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice. Cell. Immunol. 222:78-87, 2003;Weksler, ME The Immunotherapy of
Alzheimer’s Disease Immunity and
Aging 1:2-10, 2004; Szabo, P, Li, F,
Mathew, J., Lillvis, J, Weksler, M.E. Evolution of B-cell clonal expansions with age. Cell. Immunol. 231:158-67, 2004; Paul, S. Nishiyama
, Y, Planque, S., Karle S, Taguchi, Hanson, C, Weksler, ME, Antibodies as efensive Enzymes, Springer Seminars Immunopathol.
26:485-503, 2005.; Weksler M. E., Gouras, G. Relkin, N.R., Szabo, P. The Immune
System, Amyloid-beta Peptide, and Alzheimer’s Disease, Immunol. Reviews 205:244-56, 2005; Marotta, F, Weksler, M, Naito, Y, Toshida, C, Yoshioka, M, Marandola,
P. Nutraceutical
Supplementation : Effect of FPP on DNA damage in Healthy
Elderly Individuals Ann. NY Acad. Sci 1067:400, 2006
ACTIVE OTHER SUPPORT |
